Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits

1. The anti-diabetic drug miglitol, an α-glucosidase inhibitor, which is currently used clinically, reduces myocardial infarct size by reducing the glycogenolytic rate through inhibition of the α-1,6-glucosidase of glycogen-debranching enzyme in the heart. Nicorandil, a K(ATP) channel opener with a...

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Autori principali: Minatoguchi, Shinya, Wang, Ningyuan, Uno, Yoshihiro, Arai, Masazumi, Hashimoto, Kazuaki, Hashimoto, Yasuko, Chen, Xue-Hai, Takemura, Genzou, Fujiwara, Hisayoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572872/
https://ncbi.nlm.nih.gov/pubmed/11487514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704166
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