Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease

1. Caspases, key enzymes in the apoptosis pathway, have been detected in the brain of HD patients and in animal models of the disease. In the present study, we investigated the neuroprotective properties of a new, reversible, caspase-3-specific inhibitor, M826 (3-({(2S)-2-[5-tert-butyl-3-{[(4-methyl...

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Bibliografski detalji
Glavni autori: Toulmond, Sylvie, Tang, Keith, Bureau, Yves, Ashdown, Helen, Degen, Sarah, O'Donnell, Ruth, Tam, John, Han, Yongxin, Colucci, John, Giroux, André, Zhu, Yanxia, Boucher, Mathieu, Pikounis, Bill, Xanthoudakis, Steven, Roy, Sophie, Rigby, Michael, Zamboni, Robert, Robertson, George S, Ng, Gordon Y K, Nicholson, Donald W, Flückiger, Jean-Pierre
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574244/
https://ncbi.nlm.nih.gov/pubmed/14744804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705662
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