Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

1. The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABA(A) and Drosophila melanogaster homomeric RDL(ac) GABA receptors expressed in Xenopus laevis oocytes, voltage-clamped at −60 mV. The site of action of thymol was also investigated. 2. Thymol, 1–...

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Bibliografiske detaljer
Main Authors: Priestley, Caroline M, Williamson, Elizabeth M, Wafford, Keith A, Sattelle, David B
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574153/
https://ncbi.nlm.nih.gov/pubmed/14623762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705542
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