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Novel data point to a broader mechanism of action of oxidized ATP: the P2X(7) receptor is not the only target
Oxidized ATP (oATP) is a Schiff-base-forming reagent that has been used for some years as an antagonist at the P2X(7) receptor (P2X(7)R). Preincubation of mononuclear phagocytes with this inhibitor leads to attenuation of several proinflammatory responses triggered by extracellular ATP as well as a...
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| Natura: | Artigo |
| Lingua: | Inglês |
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2003
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1574057/ https://ncbi.nlm.nih.gov/pubmed/14522840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705469 |
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