A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon

1. Statins are mainly used to control hypercholesterolemia; however, recent studies have also ascribed anti-inflammatory effects to the statins. LFA703 is a novel statin-derived compound, which potently inhibits lymphocyte function antigen-1 (LFA-1, CD11a/CD18) but does not affect HMG-CoA reductase...

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Bibliographic Details
Main Authors: Wan, Min Xiu, Schramm, Rene, Klintman, Daniel, Welzenbach, Karl, Weitz-Schmidt, Gabriele, Thorlacius, Henrik
Format: Artigo
Language:Inglês
Published: 2003
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574028/
https://ncbi.nlm.nih.gov/pubmed/12970101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705432
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