2′, 3′-O-(2,4,6,Trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X(3) receptor

1. Rapid desensitization of ligand-gated ion channel receptors can alter the apparent activity of receptor modulators, as well as make detection of fast-channel activation difficult. Investigation of the antagonist pharmacology of ATP-sensitive homomeric P2X(3) receptors is limited by agonist-evoked...

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Detalhes bibliográficos
Main Authors: Neelands, Torben R, Burgard, Edward C, Uchic, Marie E, McDonald, Heath A, Niforatos, Wende, Faltynek, Connie R, Lynch, Kevin J, Jarvis, Michael F
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574009/
https://ncbi.nlm.nih.gov/pubmed/12967950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705411
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