β-adrenoceptor activation plays a role in the reverse rate-dependency of effective refractory period lengthening by dofetilide in the guinea-pig atrium, in vitro

1. Blockers of the rapid component of the delayed rectifier potassium current (I(Kr)) prolong cardiac action potential duration (APD) and effective refractory period (ERP) in a reverse rate-dependent manner. Since activation of β-adrenoceptors attenuates prolongation of APD evoked by I(Kr) blockers,...

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Main Authors: Kovács, Anikó, Magyar, János, Bányász, Tamás, Nánási, Péter P, Szénási, Gábor
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573989/
https://ncbi.nlm.nih.gov/pubmed/12922944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705395
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