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Pharmacological analysis of beta-adrenoceptor-mediated agonism in the guinea-pig, isolated, right atrium.

The recently developed, operational model of pharmacological agonism defines the efficacy of agonists by tau = [Ro]/KE, where [Ro] is the total functional concentration of receptors and KE is the concentration of agonist-occupied receptors for half-maximal effect. Theoretically, variations in [Ro] a...

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Detalhes bibliográficos
Main Authors: Black, J. W., Gerskowitch, V. P., Leff, P., Shankley, N. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1985
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987142/
https://ncbi.nlm.nih.gov/pubmed/2859066
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