Involvement of Rho-kinase in contraction of guinea-pig aorta induced by prostanoid EP(3) receptor agonists

1. The mechanism of contraction of guinea-pig isolated aorta induced by the prostanoid EP(3) receptor agonist sulprostone (0.1–300 nM) has been investigated. In 60% of the experiments, the sulprostone log concentration–response curve (maximum=15–40% of 100 nM U-46619 response; low-responders) was un...

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Detalhes bibliográficos
Main Authors: Shum, Winnie W C, Le, Geng-yun, Jones, Robert L, Gurney, Alison M, Sasaki, Yasuharu
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573987/
https://ncbi.nlm.nih.gov/pubmed/12922932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705393
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