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In vitro and ex vivo effects of a selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, CompB, on specific binding of [(3)H]N/OFQ and [(35)S]GTPγS in rat brain and spinal cord

1. A novel selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, 1-[(3R,4R)-1-cyclooctylmethyl]-3-hydroxymethyl-4-piperidyl)-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (CompB), inhibited specific binding of [(3)H]N/OFQ to crude membranes from the rat brain and spinal cord in a concent...

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Detalhes bibliográficos
Main Authors: Yamada, Shizuo, Kusaka, Toyofumi, Urayama, Akihiko, Kimura, Ryohei, Watanabe, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573970/
https://ncbi.nlm.nih.gov/pubmed/12922933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705371
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