Polarized Th1 and Th2 cells are less responsive to negative feedback by receptors coupled to the AC/cAMP system compared to freshly isolated T cells

1. The adenylyl cyclase (AC)/cyclic adenosine monophosphate (cAMP) system is known to negatively regulate transcriptional activity of T cells, thereby possibly modulating T-cell-mediated responses at the sites of inflammation. Effects of cAMP have been widely studied in freshly isolated T cells and...

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Detalhes bibliográficos
Main Authors: Heijink, Irene H, Vellenga, Edo, Borger, Peter, Postma, Dirkje S, Monchy, Jan G R de, Kauffman, Henk F
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573801/
https://ncbi.nlm.nih.gov/pubmed/12721099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705193
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