Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats

1. Ezetimibe (1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone) and its analog SCH48461 are potent and selective cholesterol absorption inhibitors that inhibit the transport of cholesterol across the intestinal wall, thereby lowering plasma cholest...

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Detalhes bibliográficos
Main Authors: van Heek, Margaret, Farley, Constance, Compton, Douglas S, Hoos, Lizbeth M, Smith-Torhan, April, Davis, Harry R
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573799/
https://ncbi.nlm.nih.gov/pubmed/12721101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705187
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