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Inhibition of G protein-activated inwardly rectifying K(+) channels by fluoxetine (Prozac)

1. The effects of fluoxetine, a commonly used antidepressant drug, on G protein-activated inwardly rectifying K(+) channels (GIRK, Kir3) were investigated using Xenopus oocyte expression assays. 2. In oocytes injected with mRNAs for GIRK1/GIRK2, GIRK2 or GIRK1/GIRK4 subunits, fluoxetine reversibly r...

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Hlavní autoři: Kobayashi, Toru, Washiyama, Kazuo, Ikeda, Kazutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573762/
https://ncbi.nlm.nih.gov/pubmed/12684268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705172
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