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Functional coupling of the human dopamine D(2) receptor with Gα(i1), Gα(i2), Gα(i3) and Gα(o) G proteins: evidence for agonist regulation of G protein selectivity
1. The human dopamine D(2long) (D(2L)) receptor was expressed with four different G proteins in Sf9 cells using the baculovirus expression system. When co-expressed with G(i)/G(o) G proteins (G(i1)α, G(i2)α, G(i3)α, or G(o)α, plus Gβ(1) and Gγ(2)), the receptor displayed a high-affinity binding site...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573727/ https://ncbi.nlm.nih.gov/pubmed/12642378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705116 |
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