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Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-D-aspartate (NMDA) receptors

1. Although the principal pharmacological targets of local anaesthetics (LAs) are voltage-gated Na(+) channels, other targets have also been suggested. Here we examined the effects of LAs on the N-methyl-D-aspartate (NMDA) receptor, a receptor involved in the process of nociception. 2. LAs (bupivaca...

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Detalhes bibliográficos
Main Authors: Sugimoto, Masahiro, Uchida, Ichiro, Mashimo, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573718/
https://ncbi.nlm.nih.gov/pubmed/12642389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705107
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