Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb

1. Activation of human platelets by thrombin is mediated by the proteolytic cleavage of two G-protein coupled protease-activated receptors, PAR-1 and PAR-4. However, thrombin also binds specifically to the platelet surface glycoprotein GPIb. It has been claimed that thrombin can induce aggregation o...

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Bibliographic Details
Main Authors: Jarvis, Gavin E, Atkinson, Ben T, Frampton, Jon, Watson, Steve P
Format: Artigo
Language:Inglês
Published: 2003
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573703/
https://ncbi.nlm.nih.gov/pubmed/12598411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705095
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