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The role of the 8-18 helix of CGRP(8-37) in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
1. The role of individual residues in the 8-18 helix of CGRP(8-37) in promoting high-affinity binding to CGRP(1) receptors expressed on rat L6 and human SK-N-MC cells has been examined. The relative potencies of various derivatives were estimated from their ability to inhibit the human αCGRP-mediate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573669/ https://ncbi.nlm.nih.gov/pubmed/12540523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705040 |
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