The use of Tris-Lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1

1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associated protein (MRP1), which are involved in cellu...

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Main Authors: Davey, Ross A, Davey, Mary W, Cullen, Karen V, Wells, Xanthe E, Francis, Craig L, Williams, Hua-Ming, Yang, Qi, Moghaddam, Minoo J, Widmer, Fred, Whittaker, Robert G
格式: Artigo
語言:Inglês
出版: 2002
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Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573608/
https://ncbi.nlm.nih.gov/pubmed/12466237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704983
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