Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors

1. Cyclo-oxygenase (COX) and lipoxygenase (LO) share a common substrate, arachidonic acid. Aspirin and related drugs inhibit COX activity. In a subset of patients with asthma aspirin induces clinical symptoms associated with increased levels of certain LO products, a phenomenon known as aspirin-sens...

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Auteurs principaux: Gray, P A, Warner, T D, Vojnovic, I, Del Soldato, P, Parikh, A, Scadding, G K, Mitchell, J A
Format: Artigo
Langue:Inglês
Publié: 2002
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Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573571/
https://ncbi.nlm.nih.gov/pubmed/12429575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704927
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