Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation

1. It is well-established that inhibitors of cyclo-oxygenase (COX) and hence of prostaglandin (PG) biosynthesis reverse inflammatory hyperalgesia and oedema in both human and animal models of inflammatory pain. 2. Paw oedema and hyperalgesia in rats were induced by injecting carrageenan (250 μg paw(...

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Detalhes bibliográficos
Main Authors: Francischi, J N, Chaves, C T, Moura, A C L, Lima, A S, Rocha, O A, Ferreira-Alves, D L, Bakhle, Y S
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573558/
https://ncbi.nlm.nih.gov/pubmed/12411415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704937
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