Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail

1. The structural features that determine the state-dependent interaction of local anaesthetics with voltage-operated sodium channels are still a matter of debate. We have studied the blockade of sodium channels by 2,6-dimethylphenol, a phenol derivative which resembles the aromatic tail of lidocain...

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Hauptverfasser: Haeseler, Gertrud, Bufler, Johannes, Merken, Sarah, Dengler, Reinhard, Aronson, Jeffrey, Leuwer, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573480/
https://ncbi.nlm.nih.gov/pubmed/12208786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704854
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