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Voltage-dependent block of normal and mutant muscle sodium channels by 4-Chloro-m-Cresol

1. The effects of 4-Chloro-m-Cresol (4-CmC) were examined on heterologously expressed wild type (WT), Paramyotonia Congenita (R1448H) and Hyperkalemic Periodic Paralysis (M1360V) mutant α-subunits of human muscle sodium channels. 2. Block of rested sodium channels caused by 4-CmC was concentration-d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Haeseler, G, Leuwer, M, Kavan, J, Würz, A, Dengler, R, Piepenbrock, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571743/
https://ncbi.nlm.nih.gov/pubmed/10578140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702896
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