Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels

1. We have investigated the effects of the sulphonylurea, glimepiride, currently used to treat type 2 diabetes, on ATP-sensitive K(+) (K(ATP)) currents of rat cardiac myocytes and on their cloned constituents Kir6.2 and SUR2A expressed in HEK 293 cells. 2. Glimepiride blocked pinacidil-activated who...

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Autores principales: Lawrence, C L, Rainbow, R D, Davies, N W, Standen, N B
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573398/
https://ncbi.nlm.nih.gov/pubmed/12086984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704770
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