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Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels
1. We have investigated the effects of the sulphonylurea, glimepiride, currently used to treat type 2 diabetes, on ATP-sensitive K(+) (K(ATP)) currents of rat cardiac myocytes and on their cloned constituents Kir6.2 and SUR2A expressed in HEK 293 cells. 2. Glimepiride blocked pinacidil-activated who...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2002
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573398/ https://ncbi.nlm.nih.gov/pubmed/12086984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704770 |
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