Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells

1. Extracellular nucleotides can activate a common purinoceptor mediating various cell responses. In this study we report that stimulation of rat mesangial cells with ATP and UTP leads to a rapid activation of the protein kinase B/Akt (PKB) pathway. Time-course studies reveal a rapid and transient p...

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Hauptverfasser: Huwiler, Andrea, Rölz, Waltraud, Dorsch, Simone, Ren, Shuyu, Pfeilschifter, Josef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573377/
https://ncbi.nlm.nih.gov/pubmed/12055130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704748
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