Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (−/−) mice

1. Intestinal xenobiotic transporters are a significant barrier to the absorption of many orally administered drugs. P-glycoprotein (PGP) is the best known, but several others, including members of the multidrug resistance-associated protein (MRP) family, are also expressed. Definitive information o...

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Bibliografiske detaljer
Main Authors: Stephens, R H, O'Neill, C A, Bennett, J, Humphrey, M, Henry, B, Rowland, M, Warhurst, G
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573329/
https://ncbi.nlm.nih.gov/pubmed/11959808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704668
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