Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats

1. This study has administered pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in DOCA-salt hypertensive rats. 2. In control rats, the elimination half-life of pirfenidone followin...

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Detalhes bibliográficos
Main Authors: Mirkovic, Stevo, Seymour, Anne-Marie L, Fenning, Andrew, Strachan, Anna, Margolin, Solomon B, Taylor, Stephen M, Brown, Lindsay
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573203/
https://ncbi.nlm.nih.gov/pubmed/11861324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704539
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