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Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats
1. This study has administered pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in DOCA-salt hypertensive rats. 2. In control rats, the elimination half-life of pirfenidone followin...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573203/ https://ncbi.nlm.nih.gov/pubmed/11861324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704539 |
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