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Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice

We examined the direct involvement of endothelial nitric oxide (eNOS) in nitrate tolerance using eNOS knockout (eNOS (−/−)) and wild-type (eNOS (+/+)) mice. Animals were treated with either nitroglycerin (NTG, 20 mg kg(−1)s.c. 3×daily for 3 days) or vehicle (5% dextrose, D5W), and nitrate tolerance...

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Autores principales: Wang, Ellen Q, Lee, Woo-In, Fung, Ho-Leung
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573162/
https://ncbi.nlm.nih.gov/pubmed/11815364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704532
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