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Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice

We examined the direct involvement of endothelial nitric oxide (eNOS) in nitrate tolerance using eNOS knockout (eNOS (−/−)) and wild-type (eNOS (+/+)) mice. Animals were treated with either nitroglycerin (NTG, 20 mg kg(−1)s.c. 3×daily for 3 days) or vehicle (5% dextrose, D5W), and nitrate tolerance...

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Main Authors: Wang, Ellen Q, Lee, Woo-In, Fung, Ho-Leung
格式: Artigo
語言:Inglês
出版: 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573162/
https://ncbi.nlm.nih.gov/pubmed/11815364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704532
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