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Effects of moderate hypothermia on sarcolemmal Na(+)/H(+) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes

1. Specific inhibitors of the sarcolemmal Na(+)/H(+) exchanger (NHE) such as cariporide are being evaluated for cardioprotective therapy during cardiac surgery. We determined the effects of moderate hypothermia (25°C), as occurs during cardiac surgery, on (1) sarcolemmal NHE activity and (2) the NHE...

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Bibliografiske detaljer
Main Authors: Hoshino, Kimihiko, Avkiran, Metin
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573089/
https://ncbi.nlm.nih.gov/pubmed/11724767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704405
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