Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres

1. We analysed the effect of dantrolene (Dan) and five newly synthesized derivatives (GIFs) on Ca(2+) release from the sarcoplasmic reticulum (SR) of mouse skeletal muscle. 2. In intact muscles, GIF-0185 reduced the size of twitch contraction induced by electrical stimulation to the same extent as D...

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Bibliographic Details
Main Authors: Ikemoto, Takaaki, Hosoya, Takamitsu, Aoyama, Hiroshi, Kihara, Yasutaka, Suzuki, Masaaki, Endo, Makoto
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573001/
https://ncbi.nlm.nih.gov/pubmed/11606312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704307
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