Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics

1. Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. 2. We expressed receptors in Xenopus oocytes. Using two-electrode voltage clamp,...

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Hlavní autoři: Hollmann, Markus W, Ritter, Carsten H, Henle, Philipp, de Klaver, Manuela, Kamatchi, Ganesan L, Durieux, Marcel E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572757/
https://ncbi.nlm.nih.gov/pubmed/11325812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704040
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