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Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives

1. We have studied the effects of four different phenol derivatives, with methyl and halogen substituents, on heterologously expressed human skeletal muscle sodium channels, in order to find structural determinants of blocking potency. 2. All compounds blocked skeletal muscle sodium channels in a co...

詳細記述

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書誌詳細
主要な著者: Haeseler, G, Piepenbrink, A, Bufler, J, Dengler, R, Aronson, J K, Piepenbrock, S, Leuwer, M
フォーマット: Artigo
言語:Inglês
出版事項: 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572741/
https://ncbi.nlm.nih.gov/pubmed/11309264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704024
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