Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor

1. In this study, we examined whether morphine dependence was inhibited by rolipram, a cyclic AMP selective phosphodiesterase inhibitor in mice, since a role for the cyclic AMP systems in the development of morphine dependence has been reported. 2. Mice, which received morphine (10 mg kg(−1) s.c.) t...

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Detalhes bibliográficos
Main Authors: Mamiya, Takayoshi, Noda, Yukihiro, Ren, Xiuhai, Hamdy, Moustafa, Furukawa, Shoei, Kameyama, Tsutomu, Yamada, Kiyofumi, Nabeshima, Toshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572651/
https://ncbi.nlm.nih.gov/pubmed/11226142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703912
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