Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones

1. The pharmacology of the slow afterhyperpolarization (sAHP) was studied in cultured rat hippocampal pyramidal neurones. 2. Clotrimazole, its in vivo metabolite, 2-chlorophenyl-bisphenyl-methanol (CBM) and the novel analogues, UCL 1880 and UCL 2027, inhibited the sI(AHP) with similar IC(50)s (1 – 2...

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Bibliographic Details
Main Authors: Shah, M M, Miscony, Z, Javadzadeh-Tabatabaie, M, Ganellin, C R, Haylett, D G
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572631/
https://ncbi.nlm.nih.gov/pubmed/11181430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703895
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