Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells

1. Hypersensitivity to the drug sulfamethoxazole (SMX) is thought to be a consequence of bioactivation to the hydroxylamine metabolite (SMX-NHOH) and further oxidation to the ultimate reactive metabolite, nitroso-sulfamethoxazole (SMX-NO). SMX-NO covalently modifies self proteins which in turn might...

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Detalhes bibliográficos
Main Authors: Burkhart, Christoph, von Greyerz, Salome, Depta, Jan P H, Naisbitt, Dean J, Britschgi, Markus, Park, Kevin B, Pichler, Werner J
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572594/
https://ncbi.nlm.nih.gov/pubmed/11159714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703845
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