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Novel mechanism of blocking axonal Na(+) channels by three macrocyclic polyamine analogues and two spider toxins
1. The mechanism of Na(+) channel block by three macrocyclic polyamine derivatives and two spider toxins was studied with voltage clamp and internal perfusion method in squid axons. 2. All these chemicals specifically block Na(+) channels in the open state only from the internal surface, and do not...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572525/ https://ncbi.nlm.nih.gov/pubmed/11156562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703765 |
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