Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747

1. CS-747 is a novel thienopyridine-type platelet ADP inhibitor which lacks in vitro activity. This study examined pharmacological profiles of R-99224, a hepatic metabolite of CS-747. 2. R-99224 produced a concentration-dependent inhibition of in vitro platelet aggregation in washed human platelets...

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Detalhes bibliográficos
Main Authors: Sugidachi, Atsuhiro, Asai, Fumitoshi, Yoneda, Kenji, Iwamura, Ryo, Ogawa, Taketoshi, Otsuguro, Ken-ichi, Koike, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572523/
https://ncbi.nlm.nih.gov/pubmed/11156560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703761
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