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Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin

1. Mice lacking the apolipoprotein E and low density lipoprotein receptor genes (E°xLDLR°) develop atherosclerosis and endothelial dysfunction. The aim of this study was to characterize the roles of L-arginine and tetrahydrobiopterin (BH(4)) for endothelium-dependent relaxation and the changes in th...

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Detalhes bibliográficos
Main Authors: Jiang, Jiahua, Valen, Guro, Tokuno, Shinichi, Thorén, Peter, Pernow, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572463/
https://ncbi.nlm.nih.gov/pubmed/11090096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703705
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