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Morphine-6β-glucuronide has a higher efficacy than morphine as a mu-opioid receptor agonist in the rat locus coeruleus
1. The pharmacological properties of the active morphine metabolite, morphine-6β-D-glucuronide (M6G), and the parent compound were compared in rat locus coeruleus neurons by electrophysiological recording in brain slices. 2. M6G and morphine activated potassium currents in voltage clamped neurons, w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572456/ https://ncbi.nlm.nih.gov/pubmed/11090116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703697 |
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