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Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrate

1. Tolerance to glyceryl trinitrate (GTN) involves superoxide (O(2)(.−)) production by endothelial cells. Nitric oxide synthase (NOS) produces O(2)(.−) when L-arginine (L-arg) is limited. The purpose of this study was to test the hypothesis that GTN stimulates NOS to increase O(2)(.−) synthesis in e...

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Detalhes bibliográficos
Main Authors: Kaesemeyer, Wayne H, Ogonowski, Alison A, Jin, Liming, Caldwell, Ruth B, Caldwell, Robert W
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572421/
https://ncbi.nlm.nih.gov/pubmed/11053225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703665
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