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Inverse agonism and neutral antagonism at a constitutively active alpha-1a adrenoceptor
1. We have studied the antagonist action of prazosin and KMD-3213 in a constitutively active mutant of the human alpha-1a adrenoceptor in which Ala(271) was substituted to Thr and was expressed in CHO cells. Inverse agonism was characterized by up-regulation of receptor density, a decrease in basal...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572343/ https://ncbi.nlm.nih.gov/pubmed/11015306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703584 |
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