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Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor α subunit: effects on channel gating and regulation by ethanol

1. Each residue in the second transmembrane segment (TM2) of the human GABA(A) receptor α(2) subunit was individually mutated to tryptophan. The wild-type or mutant α(2) subunits were expressed with the wild-type human GABA(A) receptor β(2) subunit in Xenopus oocytes, and the effects of these mutati...

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Detalhes bibliográficos
Main Authors: Ueno, Susumu, Lin, Audrey, Nikolaeva, Natalia, Trudell, James R, Mihic, S John, Harris, R Adron, Harrison, Neil L
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572307/
https://ncbi.nlm.nih.gov/pubmed/10991923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703504
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