Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor α subunit: effects on channel gating and regulation by ethanol

1. Each residue in the second transmembrane segment (TM2) of the human GABA(A) receptor α(2) subunit was individually mutated to tryptophan. The wild-type or mutant α(2) subunits were expressed with the wild-type human GABA(A) receptor β(2) subunit in Xenopus oocytes, and the effects of these mutati...

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Main Authors: Ueno, Susumu, Lin, Audrey, Nikolaeva, Natalia, Trudell, James R, Mihic, S John, Harris, R Adron, Harrison, Neil L
Format: Artigo
Jezik:Inglês
Izdano: 2000
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Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572307/
https://ncbi.nlm.nih.gov/pubmed/10991923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703504
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