Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat

We have examined the effects of Y-27632, a specific inhibitor of Rho-activated kinases (ROCK I and ROCK II) upon sustained hypoxic pulmonary vasoconstriction (HPV) in both rat isolated small intrapulmonary arteries (IPA) and perfused rat lungs in situ. Y-27632 (100 nM–3 μM) was found to cause a conc...

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Main Authors: Robertson, Tom P, Dipp, Michelle, Ward, Jeremy P T, Aaronson, Phil I, Evans, A Mark
格式: Artigo
語言:Inglês
出版: 2000
主題:
Special Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572296/
https://ncbi.nlm.nih.gov/pubmed/10960061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703537
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