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The organic cation transporter OCT2 mediates the uptake of β-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers

1. Previous studies have shown that β-adrenoceptor antagonists may be substrates of organic cation transporters in kidney and lung. In this study we examined the transport of the β-adrenoreceptor antagonists propranolol and metoprolol, in renal LLC-PK(1) cell monolayers. 2. Experiments with BCECF (2...

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Main Authors: Dudley, Adam J, Bleasby, Kelly, Brown, Colin D A
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572285/
https://ncbi.nlm.nih.gov/pubmed/10960071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703518
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