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Calcium-pH crosstalks in rat mast cells: cytosolic alkalinization, but not intracellular calcium release, is a sufficient signal for degranulation

1. The aim of this work was to study the relationship between intracellular alkalinization, calcium fluxes and histamine release in rat mast cells. Intracellular alkalinization was induced by nigericin, a monovalent cation ionophore, and by NH(4)Cl (ammonium chloride). Calcium cytosolic and intracel...

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Detalhes bibliográficos
Main Authors: Alfonso, A, Cabado, A G, Vieytes, M R, Botana, L M
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572257/
https://ncbi.nlm.nih.gov/pubmed/10952669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703490
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