Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity

Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. Following i.p. administration, nitroparacetamol inhibits carrageenan-induced hindpaw oedema formation (ED(50), 169.4 μmol kg(−1)) and mechanical hyperalgesia (ED(50), 156 μmol kg(−1)) in the rat. In c...

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Bibliographic Details
Main Authors: al-Swayeh, O A, Futter, L E, Clifford, R H, Moore, P K
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Special Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572245/
https://ncbi.nlm.nih.gov/pubmed/10928944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703509
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