FK506 potently inhibits T cell activation induced TNF-α and IL-1β production in vitro by human peripheral blood mononuclear cells

1. The aim of this study was to elucidate the in vitro inhibitory potency of FK506 on production of the inflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β, with a view to assessing this immunosuppressive agent as a potential anti-rheumatic drug. 2. We employed an in vitro...

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Detalhes bibliográficos
Main Authors: Sakuma, Shozo, Kato, Yasuko, Nishigaki, Fusako, Sasakawa, Tatsuya, Magari, Katsue, Miyata, Susumu, Ohkubo, Yoshitaka, Goto, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572228/
https://ncbi.nlm.nih.gov/pubmed/10928971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703472
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