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Structural factors that determine the ability of adenosine and related compounds to activate the cardiac ryanodine receptor

1. The effects of adenosine and adenine on the gating of native sheep cardiac ryanodine receptor (RyR) channels were investigated. By examining the mechanisms underlying channel activation and by using comparative molecular field analysis (CoMFA) we have investigated the structural features of adeni...

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Hlavní autoři: Chan, Wei Mun, Welch, William, Sitsapesan, Rebecca
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572218/
https://ncbi.nlm.nih.gov/pubmed/10928966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703459
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